TGFBI

Across TCGA patient cohorts, TGFBI mutation is significantly associated with the RNA expression of many other genes, with 4,102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFBI-associated genes across cancer lineages are GAPDHP56, VDAC2, and FN3K. Each is linked with TGFBI in more than 2 cancer types. Because this analysis shows association rather than direction, both TGFBI-to-partner and partner-to-TGFBI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDHP56 grouped by TGFBI-low versus TGFBI-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBI→partner) and Y-score (partner→TGFBI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GAPDHP56 →	+0.027	+4.920	.009	.004	3	3
SKCM	VDAC2 →	+0.507	+2.913	<.001	.001	3	3
SKCM	FN3K →	+0.839	+2.925	.002	.001	3	3
SKCM	UQCRH →	+0.456	+3.623	.005	.001	3	3
SKCM	VDAC1 →	+0.530	+4.019	<.001	<.001	3	3
SKCM	NPM1P39 →	+0.479	+2.266	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,102 associations by consensus.

GAPDHP56 by TGFBI expression — BRCA

Explore this box plot interactively →