TGFBI

Across TCGA patient cohorts, TGFBI mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFBI-associated genes across cancer lineages are MEK1, Notch1, and ATM. Each is linked with TGFBI in more than 2 cancer types. Because this analysis shows association rather than direction, both TGFBI-to-partner and partner-to-TGFBI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TGFBI-low versus TGFBI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBI→partner) and Y-score (partner→TGFBI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.450	+2.115	<.001	<.001	3	3
UCEC	Notch1 →	+0.149	+1.920	<.001	.008	3	3
UCEC	ATM →	-0.385	-1.906	.006	.015	3	3
UCEC	4E-BP1 →	+0.300	+3.807	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.651	+3.169	<.001	<.001	3	3
UCEC	PCNA →	+0.230	+2.115	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MEK1 by TGFBI expression — UCEC

Explore this box plot interactively →