TGFBI

Across TCGA cell cohorts, TGFBI mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TGFBI-associated genes across cancer lineages are MYF5, FABP12, and MAGEB5. Each is linked with TGFBI in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFBI-to-partner and partner-to-TGFBI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF5 grouped by TGFBI-low versus TGFBI-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBI→partner) and Y-score (partner→TGFBI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MYF5 →	+0.016	+4.807	<.001	.006	3	1
BLOOD_Myeloma	FABP12 →	+0.060	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Leukemia	KLRD1 →	+0.128	+3.091	.001	.006	3	1
BLOOD_Leukemia	HIPK4 →	+0.064	+3.722	<.001	.002	3	1
BLOOD_Leukemia	DEFB108B →	+0.090	+3.269	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MYF5 by TGFBI expression — BLOOD_Myeloma

Explore this box plot interactively →