TGFB3

Across TCGA pan-cancer cohorts, TGFB3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TGFB3 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TGFB3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TGFB3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, GBM, and CCRCC are the cancer types where TGFB3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.522	0.856	.005	34	view →
GBM	DFS	Tertile	All	0.678	0.828	.015	9	view →
CCRCC	DFS	Quartile	All	0.518	1.000	.019	8	view →
LUAD	DFS	Median	II,III,IV	0.722	0.447	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TGFB3–LSCC (DFS)

Open the LSCC breakdown →