TGFB3

Across TCGA patient cohorts, TGFB3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFB3-associated genes across cancer lineages are ERK2, GAPDH, and Heregulin. Each is linked with TGFB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFB3-to-partner and partner-to-TGFB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TGFB3-low versus TGFB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB3→partner) and Y-score (partner→TGFB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.168	+3.321	.026	.009	3	2
UCEC	GAPDH →	+0.444	+1.584	.035	.036	3	2
UCEC	Heregulin →	-0.105	-3.156	.030	.018	3	1
UCEC	MSH2 →	-0.254	-2.295	.005	.033	3	1
UCEC	MSH6 →	-0.369	-1.874	.004	.049	3	1
UCEC	p62 Lck ligand →	+0.309	+3.169	.015	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by TGFB3 expression — UCEC

Explore this box plot interactively →