TGFB3

Across TCGA cell cohorts, TGFB3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGFB3-associated genes across cancer lineages are MS4A4A, MCHR2, and C1orf189. Each is linked with TGFB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFB3-to-partner and partner-to-TGFB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by TGFB3-low versus TGFB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB3→partner) and Y-score (partner→TGFB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.179	+3.263	<.001	.001	3	1
LARGE_INTESTINE	MCHR2 →	+0.014	+3.099	.004	.002	3	1
LARGE_INTESTINE	C1orf189 →	+0.108	+2.791	<.001	.005	3	1
LARGE_INTESTINE	ZNF454 →	+0.189	+2.921	.003	.005	3	1
LARGE_INTESTINE	TAFA1 →	+0.206	+3.425	.004	<.001	3	1
LARGE_INTESTINE	CLPSL1 →	+0.141	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MS4A4A by TGFB3 expression — LARGE_INTESTINE

Explore this box plot interactively →