TGFB1I1

Across TCGA pan-cancer cohorts, TGFB1I1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TGFB1I1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TGFB1I1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TGFB1I1 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and HNSC are the cancer types where TGFB1I1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TGFB1I1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.574	<.001	11	view →
LUAD	Male	III,IV	−0.925	<.001	9	view →
HNSC	All	All	−0.341	<.001	9	view →
LSCC	Female	All	−1.222	<.001	8	view →
PDAC	Female	All	+0.886	<.001	8	view →
CCRCC	Male	III,IV	−0.713	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TGFB1I1–COAD

Open the COAD breakdown →