TGFB1I1

Across TCGA patient cohorts, TGFB1I1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFB1I1-associated genes across cancer lineages are GATA6, ATM, and Bax. Each is linked with TGFB1I1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGFB1I1-to-partner and partner-to-TGFB1I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by TGFB1I1-low versus TGFB1I1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB1I1→partner) and Y-score (partner→TGFB1I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.175	-2.577	.015	.011	3	2
UCEC	ATM →	-0.498	-2.115	.011	.019	3	2
UCEC	Bax →	+0.298	+1.884	.004	.030	3	2
UCEC	beta-Catenin →	+0.447	+2.115	.043	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.690	+3.479	.007	.002	3	2
UCEC	4E-BP1 →	+0.236	+3.199	.046	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

GATA6 by TGFB1I1 expression — UCEC

Explore this box plot interactively →