TGFB1I1

Across TCGA cell cohorts, TGFB1I1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGFB1I1-associated genes across cancer lineages are GIMAP7, CST8, and MMP26. Each is linked with TGFB1I1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFB1I1-to-partner and partner-to-TGFB1I1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GIMAP7 grouped by TGFB1I1-low versus TGFB1I1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB1I1→partner) and Y-score (partner→TGFB1I1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GIMAP7 →	+0.054	+4.169	<.001	.008	3	1
BLOOD_Leukemia	CST8 →	+0.052	+4.969	<.001	.003	3	1
LARGE_INTESTINE	MMP26 →	+0.052	+3.632	<.001	.003	3	1
LARGE_INTESTINE	KRT1 →	+0.586	+3.509	<.001	.008	3	1
LARGE_INTESTINE	ANO5 →	+0.640	+3.453	.001	.009	3	1
LARGE_INTESTINE	FAM218A →	+0.390	+3.658	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GIMAP7 by TGFB1I1 expression — CNS

Explore this box plot interactively →