TGFB1

Across TCGA pan-cancer cohorts, TGFB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TGFB1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TGFB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TGFB1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, GBM, and LSCC are the cancer types where TGFB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.802	0.968	.005	25	view →
GBM	DFS	Quartile	All	0.238	0.544	.002	14	view →
LSCC	OS	Median	All	0.702	0.913	<.001	10	view →
HNSC	OS	Quartile	All	1.000	0.931	.034	9	view →
PDAC	OS	Tertile	II,III,IV	0.425	0.629	.006	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TGFB1–CCRCC (DFS)

Open the CCRCC breakdown →