TGFB1

Across TCGA pan-cancer cohorts, TGFB1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TGFB1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where TGFB1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TGFB1 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

CCRCC, HNSC, and LUAD are the cancer types where TGFB1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TGFB1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	+1.188	<.001	12	view →
HNSC	Male	All	+0.550	<.001	12	view →
LUAD	Male	All	−0.198	<.001	8	view →
PDAC	Female	All	+0.864	<.001	6	view →
LSCC	Male	All	−0.154	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TGFB1–CCRCC

Open the CCRCC breakdown →