TGFB1

Across TCGA patient cohorts, TGFB1 protein abundance is significantly associated with the protein abundance of many other proteins, with 23,131 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TGFB1-associated proteins across cancer lineages are TGFBI, RCN3, and FN1. Each is linked with TGFB1 in more than 7 cancer types. Because this analysis shows association rather than direction, both TGFB1-to-partner and partner-to-TGFB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TGFB1 versus TGFBI in CCRCC, with a Pearson correlation of 0.46.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB1→partner) and Y-score (partner→TGFB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TGFBI →	+0.854	+0.403	<.001	<.001	3	8
GBM	RCN3 →	+0.746	+0.447	<.001	<.001	3	8
OV	FN1 →	+1.514	+0.704	<.001	<.001	3	8
COAD	ILK →	+0.479	+0.466	<.001	<.001	3	8
COAD	ITGA5 →	+0.713	+0.651	<.001	<.001	3	8
BRCA	MSN →	+0.451	+0.390	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,131 associations by consensus.

TGFB1 vs TGFBI — CCRCC

Explore this scatter interactively →