TGFB1

Across TCGA cell cohorts, TGFB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,839 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TGFB1-associated GO terms across cancer lineages are Negative regulation of natural killer cell mediated immune response to tumor cell, Negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, and Regulatory T cell differentiation. Each is linked with TGFB1 in more than 19 cancer types. Because this analysis shows association rather than direction, both TGFB1-to-partner and partner-to-TGFB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of natural killer cell mediated immune response to tumor cell grouped by TGFB1-low versus TGFB1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFB1→partner) and Y-score (partner→TGFB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of natural killer cell mediated immune response to tumor cell →	+1.447	+2.625	<.001	<.001	3	20
BREAST	Negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target →	+1.447	+2.625	<.001	<.001	3	20
SKIN	Regulatory T cell differentiation →	+1.729	+2.149	<.001	<.001	3	19
LUNG_SCLC	Response to acetaldehyde →	+1.204	+2.262	<.001	<.001	3	18
LUNG_SCLC	Cellular response to acetaldehyde →	+1.204	+2.262	<.001	<.001	3	18
OESOPHAGUS	Regulation of hyaluronan biosynthetic process →	+0.223	+1.895	<.001	.006	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,839 associations by consensus.

Negative regulation of natural killer cell mediated immune response to tumor cell by TGFB1 expression — BREAST

Explore this box plot interactively →