Across TCGA pan-cancer cohorts, TGFA-IT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated TGFA-IT1 data layer.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TGFA-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TGFA-IT1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and LAML show a favorable association.
KIRP, UCEC, and LIHC are the cancer types where TGFA-IT1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.