TG

Across TCGA patient cohorts, TG mutation is significantly associated with the RNA expression of many other genes, with 10,352 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TG-associated genes across cancer lineages are POC1A, ZNF367, and SNRPD1. Each is linked with TG in more than 5 cancer types. Because this analysis shows association rather than direction, both TG-to-partner and partner-to-TG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POC1A grouped by TG-low versus TG-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TG→partner) and Y-score (partner→TG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	POC1A →	+0.510	+1.596	.001	.006	3	6
UCEC	ZNF367 →	+0.641	+1.542	<.001	<.001	3	6
COAD	SNRPD1 →	+0.492	+2.750	<.001	<.001	3	6
SKCM	RPL23AP7 →	+0.394	+1.733	<.001	.001	3	6
HNSC	ZNF165 →	+0.583	+2.231	<.001	.006	3	6
LUAD	EXOSC9 →	+0.423	+2.236	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,352 associations by consensus.

POC1A by TG expression — LUAD

Explore this box plot interactively →