TG

Across TCGA patient cohorts, TG mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TG-associated genes across cancer lineages are PAI-1, MSH6, and 4E-BP1. Each is linked with TG in more than 3 cancer types. Because this analysis shows association rather than direction, both TG-to-partner and partner-to-TG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by TG-low versus TG-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TG→partner) and Y-score (partner→TG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PAI-1 →	+0.589	+2.824	.033	.034	3	4
LUSC	MSH6 →	+0.352	+2.459	.015	.018	3	4
LUAD	4E-BP1 →	+0.314	+1.700	.009	.043	3	4
COAD	EGFR_pY1068 →	-0.283	-2.321	.014	.032	3	4
COAD	Caspase-7-cleavedD198 →	+0.971	+2.008	<.001	.005	3	4
UCEC	GAPDH →	+0.264	+1.000	.023	.013	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

PAI-1 by TG expression — BLCA

Explore this box plot interactively →