TG

Across TCGA cell cohorts, TG RNA expression is significantly associated with the go_rna of many other GO terms, with 2,048 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TG-associated GO terms across cancer lineages are Regulation of amino acid biosynthetic process, COPII-coated vesicle budding, and Response to endoplasmic reticulum stress. Each is linked with TG in more than 7 cancer types. Because this analysis shows association rather than direction, both TG-to-partner and partner-to-TG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of amino acid biosynthetic process grouped by TG-low versus TG-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TG→partner) and Y-score (partner→TG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of amino acid biosynthetic process →	+0.138	+0.298	<.001	<.001	3	8
SKIN	COPII-coated vesicle budding →	+0.048	+0.322	.001	.004	3	8
LUNG_NSCLC_LUSC	Response to endoplasmic reticulum stress →	+0.050	+0.489	<.001	.002	3	8
LUNG_SCLC	Motile cilium assembly →	-0.026	-0.155	.003	.008	2	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.095	+0.439	.001	.003	3	7
LUNG_NSCLC_LUSC	ERAD pathway →	+0.066	+0.628	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,048 associations by consensus.

Regulation of amino acid biosynthetic process by TG expression — BLOOD_Leukemia

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