TG

Across TCGA cell cohorts, TG mutation is significantly associated with the RNA expression of many other genes, with 1,987 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TG-associated genes across cancer lineages are PKD2, OR1J2, and TLE6. Each is linked with TG in more than 3 cancer types. Because this analysis shows association rather than direction, both TG-to-partner and partner-to-TG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKD2 grouped by TG-low versus TG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TG→partner) and Y-score (partner→TG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PKD2 →	+0.690	+2.491	.006	.003	3	4
BLOOD_Leukemia	OR1J2 →	+0.051	+2.959	.004	.005	3	3
LARGE_INTESTINE	TLE6 →	+0.740	+1.891	.002	<.001	3	3
LARGE_INTESTINE	CRACD →	+0.834	+1.545	.001	.004	3	3
LARGE_INTESTINE	HSPA9 →	+0.489	+2.000	.001	.009	3	3
LARGE_INTESTINE	PAPOLG →	+0.512	+1.977	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,987 associations by consensus.

PKD2 by TG expression — LARGE_INTESTINE

Explore this box plot interactively →