TFRC

Across TCGA pan-cancer cohorts, TFRC Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TFRC data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TFRC Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TFRC expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, COAD, and PRAD are the cancer types where TFRC Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.027	0.907	<.001	24	view →
COAD	OS	Median	All	0.117	0.809	<.001	15	view →
PRAD	DFS	Median	All	0.157	0.888	<.001	12	view →
UCEC	DFS	Median	All	0.964	0.618	.013	10	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TFRC–BRCA (OS)

Open the BRCA breakdown →