TFRC

Across TCGA pan-cancer cohorts, TFRC mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TFRC data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TFRC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TFRC expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where TFRC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.262	0.566	.001	45	view →
CCRCC	OS	Quartile	All	0.750	0.943	.008	14	view →
LUAD	DFS	Tertile	All	0.621	0.926	.011	11	view →
HNSC	DFS	Median	All	0.698	1.000	.020	8	view →
UCEC	DFS	Tertile	All	0.771	0.944	.028	4	view →
LSCC	DFS	Median	II,III,IV	0.807	0.572	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TFRC–PDAC (DFS)

Open the PDAC breakdown →