TFRC

Across TCGA patient cohorts, TFRC mutation is significantly associated with the RNA expression of many other genes, with 1,833 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFRC-associated genes across cancer lineages are BORCS7-ASMT, RNU6-709P, and RN7SL97P. Each is linked with TFRC in more than 2 cancer types. Because this analysis shows association rather than direction, both TFRC-to-partner and partner-to-TFRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BORCS7-ASMT grouped by TFRC-low versus TFRC-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFRC→partner) and Y-score (partner→TFRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	BORCS7-ASMT →	+0.024	+4.984	<.001	.009	3	3
COAD	RNU6-709P →	+0.592	+5.557	<.001	.001	3	3
CESC	RN7SL97P →	+0.123	+4.559	<.001	.006	3	2
BRCA	OR5M5P →	+0.076	+4.610	<.001	.008	3	2
BRCA	RNU6-374P →	+0.106	+7.473	<.001	.007	3	2
BRCA	ELOCP36 →	+0.039	+7.473	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,833 associations by consensus.

BORCS7-ASMT by TFRC expression — LUSC

Explore this box plot interactively →