TFRC

Across TCGA patient cohorts, TFRC mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFRC-associated genes across cancer lineages are FASN, Cyclin-E2, and EGFR_pY1068. Each is linked with TFRC in more than 1 cancer types. Because this analysis shows association rather than direction, both TFRC-to-partner and partner-to-TFRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by TFRC-low versus TFRC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFRC→partner) and Y-score (partner→TFRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.424	+2.459	.002	.018	3	2
UCEC	Cyclin-E2 →	+0.208	+2.817	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.214	-1.584	.017	.019	3	1
UCEC	eIF4E →	+0.230	+3.920	.002	<.001	3	1
UCEC	A-Raf_pS299 →	-0.116	-3.169	.007	.018	3	1
UCEC	ERK2 →	+0.220	+2.584	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

FASN by TFRC expression — UCEC

Explore this box plot interactively →