TFRC

Across TCGA cell cohorts, TFRC RNA expression is significantly associated with the go_rna of many other GO terms, with 3,388 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TFRC-associated GO terms across cancer lineages are Ribosomal subunit export from nucleus, Ribosome localization, and Regulation of chromosome condensation. Each is linked with TFRC in more than 14 cancer types. Because this analysis shows association rather than direction, both TFRC-to-partner and partner-to-TFRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosomal subunit export from nucleus grouped by TFRC-low versus TFRC-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFRC→partner) and Y-score (partner→TFRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Ribosomal subunit export from nucleus →	+0.139	+1.354	<.001	.005	2	15
LIVER	Ribosome localization →	+0.139	+1.354	<.001	.005	2	15
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome condensation →	+0.166	+1.361	.001	.002	3	13
LUNG_NSCLC_LUSC	Maintenance of centrosome location →	+0.158	+1.314	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mRNA processing →	+0.110	+1.469	<.001	<.001	3	11
LUNG_SCLC	Regulation of DNA stability →	+0.112	+0.747	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,388 associations by consensus.

Ribosomal subunit export from nucleus by TFRC expression — LIVER

Explore this box plot interactively →