TFR2

Across TCGA patient cohorts, TFR2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFR2-associated genes across cancer lineages are JNK2, Annexin-1, and p38-MAPK. Each is linked with TFR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFR2-to-partner and partner-to-TFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by TFR2-low versus TFR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFR2→partner) and Y-score (partner→TFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.259	+2.000	<.001	.003	3	2
UCEC	Annexin-1 →	+0.609	+3.700	.001	.001	3	2
SKCM	p38-MAPK →	+0.164	+2.115	.028	.018	3	1
SKCM	AMPK_alpha →	+0.120	+2.321	.049	.033	3	1
SKCM	S6_pS235_S236 →	-0.443	-2.987	.016	.035	3	1
UCEC	EGFR_pY1068 →	-0.194	-1.362	.028	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

JNK2 by TFR2 expression — UCEC

Explore this box plot interactively →