TFPT

Across TCGA pan-cancer cohorts, TFPT mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TFPT data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TFPT mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TFPT expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and GBM are the cancer types where TFPT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.869	0.322	<.001	64	view →
LSCC	DFS	Tertile	All	0.846	0.560	.010	15	view →
GBM	OS	Tertile	All	1.000	0.809	.012	11	view →
UCEC	DFS	Median	All	1.000	0.929	.024	4	view →
LUAD	OS	Median	All	0.934	0.721	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TFPT–HNSC (DFS)

Open the HNSC breakdown →