TFPT

Across TCGA patient cohorts, TFPT mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFPT-associated genes across cancer lineages are 4E-BP1, p62 Lck ligand, and Cyclin-B1. Each is linked with TFPT in more than 1 cancer types. Because this analysis shows association rather than direction, both TFPT-to-partner and partner-to-TFPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by TFPT-low versus TFPT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFPT→partner) and Y-score (partner→TFPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.318	+2.837	.015	.035	2	2
UCEC	p62 Lck ligand →	+0.412	+2.459	.008	.020	1	1
UCEC	Cyclin-B1 →	+0.759	+2.459	.005	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

4E-BP1 by TFPT expression — UCEC

Explore this box plot interactively →