TFPT

Across TCGA cell cohorts, TFPT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,046 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TFPT-associated GO terms across cancer lineages are Regulation of telomere maintenance in response to DNA damage, Positive regulation of telomere maintenance in response to DNA damage, and Regulation of DNA strand elongation. Each is linked with TFPT in more than 12 cancer types. Because this analysis shows association rather than direction, both TFPT-to-partner and partner-to-TFPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomere maintenance in response to DNA damage grouped by TFPT-low versus TFPT-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFPT→partner) and Y-score (partner→TFPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of telomere maintenance in response to DNA damage →	+0.085	+0.733	.002	.002	2	13
PANCREAS	Positive regulation of telomere maintenance in response to DNA damage →	+0.103	+0.980	<.001	<.001	3	12
PANCREAS	Regulation of DNA strand elongation →	+0.081	+0.804	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to organelle →	+0.048	+0.785	.001	.001	3	9
BLOOD_Leukemia	Free ubiquitin chain polymerization →	+0.133	+0.511	<.001	.006	3	8
OVARY	Germ cell development →	-0.027	-0.781	.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,046 associations by consensus.

Regulation of telomere maintenance in response to DNA damage by TFPT expression — STOMACH

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