TFPT

Across TCGA cell cohorts, TFPT mutation is significantly associated with the drug of many other genes, with 45 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFPT-associated genes across cancer lineages are Niraparib, LCL161, and AZD5153. Each is linked with TFPT in more than 1 cancer types. Because this analysis shows association rather than direction, both TFPT-to-partner and partner-to-TFPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by TFPT-low versus TFPT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFPT→partner) and Y-score (partner→TFPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.465	+2.678	.008	.037	3	1
LARGE_INTESTINE	LCL161 →	+0.356	+2.646	.028	.047	3	1
LARGE_INTESTINE	AZD5153 →	+0.545	+2.649	.030	.046	3	1
LARGE_INTESTINE	PAK_5339 →	+0.398	+2.678	.006	.037	3	1
LARGE_INTESTINE	50869 →	+0.442	+2.649	.037	.046	3	1
LARGE_INTESTINE	150412 →	+0.555	+2.777	<.001	.038	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Niraparib by TFPT expression — LARGE_INTESTINE

Explore this box plot interactively →