TFPI2

Across TCGA patient cohorts, TFPI2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFPI2-associated genes across cancer lineages are p90 RSK, mTOR, and p62 Lck ligand. Each is linked with TFPI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFPI2-to-partner and partner-to-TFPI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by TFPI2-low versus TFPI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFPI2→partner) and Y-score (partner→TFPI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.257	+3.013	.020	.019	3	1
UCEC	mTOR →	+0.245	+3.000	.008	.037	1	1
UCEC	p62 Lck ligand →	+0.485	+3.000	.009	.037	1	1
UCEC	4E-BP1 →	+0.322	+3.000	.039	.037	1	1
UCEC	Cyclin-B1 →	+0.977	+3.000	.002	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p90 RSK by TFPI2 expression — UCEC

Explore this box plot interactively →