TFPI2

Across TCGA cell cohorts, TFPI2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,613 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TFPI2-associated GO terms across cancer lineages are Regulation of cell-substrate junction organization, Viral process, and Regulation of focal adhesion assembly. Each is linked with TFPI2 in more than 10 cancer types. Because this analysis shows association rather than direction, both TFPI2-to-partner and partner-to-TFPI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction organization grouped by TFPI2-low versus TFPI2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFPI2→partner) and Y-score (partner→TFPI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate junction organization →	+0.117	+2.513	.006	.002	3	11
OESOPHAGUS	Viral process →	+0.077	+2.306	.001	.001	3	10
BONE	Regulation of focal adhesion assembly →	+0.131	+2.513	.004	.002	3	10
BONE	Regulation of cell-substrate junction assembly →	+0.131	+2.513	.004	.002	3	10
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate adhesion →	+0.127	+4.267	.001	<.001	2	10
BREAST	Viral life cycle →	+0.085	+2.852	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,613 associations by consensus.

Regulation of cell-substrate junction organization by TFPI2 expression — BONE

Explore this box plot interactively →