TFPI2

Across TCGA cell cohorts, TFPI2 mutation is significantly associated with the mutation status of many other genes, with 2,493 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFPI2-associated genes across cancer lineages are KATNIP, TRDMT1, and OR2T1. Each is linked with TFPI2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TFPI2-to-partner and partner-to-TFPI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KATNIP grouped by TFPI2-low versus TFPI2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFPI2→partner) and Y-score (partner→TFPI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KATNIP →	+2.152	+2.787	.005	.005	1	3
OVARY	TRDMT1 →	+4.977	+4.415	.007	.007	1	3
LARGE_INTESTINE	OR2T1 →	+3.000	+3.000	.003	.003	1	3
LARGE_INTESTINE	SLC4A11 →	+2.000	+2.662	.008	.008	1	2
LARGE_INTESTINE	RBM41 →	+3.584	+3.007	.008	.008	1	2
LARGE_INTESTINE	ZNF268 →	+2.736	+3.208	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,493 associations by consensus.

KATNIP by TFPI2 expression — LARGE_INTESTINE

Explore this box plot interactively →