TFPI

Across TCGA pan-cancer cohorts, TFPI mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TFPI data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TFPI mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TFPI expression acts as an unfavorable survival marker.

PDAC, CCRCC, and LUAD are the cancer types where TFPI mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.369	0.753	<.001	69	view →
CCRCC	DFS	Quartile	All	0.407	0.856	.001	61	view →
LUAD	OS	Median	III,IV	0.229	0.717	.010	8	view →
UCEC	OS	Median	III,IV	0.306	0.891	.025	4	view →
HNSC	DFS	Median	All	0.924	0.985	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TFPI–PDAC (OS)

Open the PDAC breakdown →