TFG

Across TCGA pan-cancer cohorts, TFG mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TFG’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where TFG mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TFG is over-expressed in tumor, although a few such as PDAC and COAD show the opposite, repressed pattern.

PDAC, LSCC, and OV are the cancer types where TFG tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TFG mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−0.678	<.001	8	view →
LSCC	All	All	+0.075	.009	5	view →
OV	All	All	+0.178	.034	2	view →
COAD	Male	II,III,IV	−0.091	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TFG–PDAC

Open the PDAC breakdown →