TFG

Across TCGA patient cohorts, TFG mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFG-associated genes across cancer lineages are ETS-1, mTOR, and PEA-15_pS116. Each is linked with TFG in more than 1 cancer types. Because this analysis shows association rather than direction, both TFG-to-partner and partner-to-TFG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETS-1 grouped by TFG-low versus TFG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFG→partner) and Y-score (partner→TFG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ETS-1 →	+0.316	+3.169	.039	.019	3	2
UCEC	mTOR →	-0.176	-3.169	.024	.019	3	1
UCEC	PEA-15_pS116 →	+0.459	+2.459	.006	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.822	+3.019	.004	.019	3	1
UCEC	Chk2 →	-0.308	-3.584	.006	.002	3	1
UCEC	ERK2 →	+0.366	+3.584	<.001	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ETS-1 by TFG expression — UCEC

Explore this box plot interactively →