TFG

Across TCGA cell cohorts, TFG mutation is significantly associated with the drug of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TFG-associated genes across cancer lineages are TL-2-105, Quizartinib, and SU11274. Each is linked with TFG in more than 1 cancer types. Because this analysis shows association rather than direction, both TFG-to-partner and partner-to-TFG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TL-2-105 grouped by TFG-low versus TFG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFG→partner) and Y-score (partner→TFG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TL-2-105 →	+0.407	+2.652	.039	.045	3	1
LARGE_INTESTINE	Quizartinib →	+0.481	+2.652	.002	.045	3	1
LARGE_INTESTINE	SU11274 →	+0.487	+2.652	.018	.045	3	1
LARGE_INTESTINE	CD532 →	+0.461	+2.652	.021	.045	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.288	+2.649	.042	.046	2	1
LARGE_INTESTINE	GSK2110183B →	+0.633	+2.649	.037	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

TL-2-105 by TFG expression — LARGE_INTESTINE

Explore this box plot interactively →