TFF3

Across TCGA pan-cancer cohorts, TFF3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TFF3 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TFF3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TFF3 expression acts as an unfavorable survival marker, although some lineages such as UVM and UCEC show a favorable association.

UVM, UCEC, and BRCA are the cancer types where TFF3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.778	0.410	<.001	113	view →
UCEC	DFS	Median	All	0.730	0.564	<.001	88	view →
BRCA	OS	Median	II,III,IV	0.943	0.882	<.001	73	view →
LGG	OS	Median	All	0.750	0.865	<.001	35	view →
ESCA	DFS	Tertile	All	0.348	1.000	<.001	33	view →
KIRP	DFS	Quartile	All	0.626	0.822	.014	25	view →
UCS	DFS	Median	All	0.142	0.403	.005	22	view →
HNSC	DFS	Median	II,III,IV	0.753	0.637	.009	22	view →
LAML	DFS	Tertile	All	0.643	0.482	.023	18	view →
KICH	DFS	Quartile	III,IV	0.214	0.931	.001	18	view →
BLCA	DFS	Quartile	III,IV	0.182	0.423	.009	17	view →
PCPG	DFS	Median	All	0.866	0.626	.014	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TFF3–UVM (OS)

Open the UVM breakdown →