TFF3

Across TCGA pan-cancer cohorts, TFF3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TFF3 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TFF3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TFF3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and LSCC are the cancer types where TFF3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.698	0.355	<.001	56	view →
UCEC	DFS	Median	All	0.936	0.774	.015	14	view →
LSCC	OS	Median	All	0.774	0.987	.008	10	view →
LUAD	OS	Median	All	0.752	0.945	.010	9	view →
CCRCC	DFS	Tertile	IV	0.961	0.138	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TFF3–PDAC (OS)

Open the PDAC breakdown →