TFF2

Across TCGA patient cohorts, TFF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,983 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible TFF2-associated GO terms across cancer lineages are Maintenance of gastrointestinal epithelium, Epithelial structure maintenance, and O-glycan processing. Each is linked with TFF2 in more than 11 cancer types. Because this analysis shows association rather than direction, both TFF2-to-partner and partner-to-TFF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of gastrointestinal epithelium grouped by TFF2-low versus TFF2-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFF2→partner) and Y-score (partner→TFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Maintenance of gastrointestinal epithelium →	+0.126	+4.411	<.001	<.001	3	12
ESCA	Epithelial structure maintenance →	+0.088	+4.146	<.001	<.001	3	11
ESCA	O-glycan processing →	+0.035	+2.383	<.001	<.001	3	10
ESCA	Glucose import across plasma membrane →	+0.079	+2.582	<.001	<.001	3	10
ESCA	Tight junction organization →	+0.045	+3.166	<.001	<.001	3	9
ESCA	Monosaccharide metabolic process →	+0.026	+1.966	.001	.003	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,983 associations by consensus.

Maintenance of gastrointestinal epithelium by TFF2 expression — ESCA

Explore this box plot interactively →