TFF2

Across TCGA patient cohorts, TFF2 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TFF2-associated genes across cancer lineages are NDUFA5P8, LINC01639, and RBAK-RBAKDN. Each is linked with TFF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFF2-to-partner and partner-to-TFF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA5P8 grouped by TFF2-low versus TFF2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFF2→partner) and Y-score (partner→TFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NDUFA5P8 →	+0.098	+4.984	.004	.005	3	2
UCEC	LINC01639 →	+0.580	+4.010	.003	<.001	3	2
UCEC	RBAK-RBAKDN →	+0.097	+2.753	.007	.009	3	1
LUAD	SLC17A2 →	+0.613	+4.293	<.001	.008	3	1
LUAD	OR7E97P →	+0.051	+5.912	<.001	.001	3	1
LUAD	OR7E129P →	+0.113	+5.076	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

NDUFA5P8 by TFF2 expression — LUAD

Explore this box plot interactively →