TFF2

Across TCGA patient cohorts, TFF2 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFF2-associated genes across cancer lineages are HSC, Neutrophils, and Th2 cells. Each is linked with TFF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFF2-to-partner and partner-to-TFF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSC grouped by TFF2-low versus TFF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFF2→partner) and Y-score (partner→TFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSC →	+0.140	+2.828	.027	.035	3	1
UCEC	Neutrophils →	+0.018	+3.166	.001	.001	3	1
UCEC	Th2 cells →	+0.380	+3.000	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

HSC by TFF2 expression — UCEC

Explore this box plot interactively →