TFF2

Across TCGA cell cohorts, TFF2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TFF2-associated genes across cancer lineages are PRSS54, OR13C7, and PRAMEF1. Each is linked with TFF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFF2-to-partner and partner-to-TFF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by TFF2-low versus TFF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFF2→partner) and Y-score (partner→TFF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRSS54 →	+0.058	+4.930	<.001	.001	3	1
LARGE_INTESTINE	OR13C7 →	+0.019	+4.415	<.001	.007	3	1
BLOOD_Leukemia	PRAMEF1 →	+0.016	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	C1orf87 →	+0.025	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10G3 →	+0.046	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MRGPRX4 →	+0.022	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PRSS54 by TFF2 expression — LARGE_INTESTINE

Explore this box plot interactively →