TFEB

Across TCGA pan-cancer cohorts, TFEB Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TFEB data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TFEB Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TFEB expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

HNSC, UCEC, and LUSC are the cancer types where TFEB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.079	0.768	<.001	24	view →
UCEC	OS	Median	All	0.966	0.657	.026	14	view →
LUSC	OS	Median	All	0.081	0.818	.008	6	view →
SKCM	OS	Median	II,III,IV	1.000	0.834	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TFEB–HNSC (OS)

Open the HNSC breakdown →