TFEB

Across TCGA pan-cancer cohorts, TFEB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TFEB data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TFEB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TFEB expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where TFEB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.979	0.304	<.001	32	view →
CCRCC	DFS	Tertile	All	0.901	0.637	.004	17	view →
GBM	OS	Quartile	All	0.401	0.668	.003	15	view →
HNSC	DFS	Quartile	III,IV	0.389	0.747	.002	15	view →
LSCC	DFS	Tertile	II,III,IV	0.514	0.812	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TFEB–PDAC (DFS)

Open the PDAC breakdown →