TFEB

Across TCGA patient cohorts, TFEB protein abundance is significantly associated with the protein abundance of many other proteins, with 28,013 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TFEB-associated proteins across cancer lineages are RASAL3, RCSD1, and TFEB_S423. Each is linked with TFEB in more than 7 cancer types. Because this analysis shows association rather than direction, both TFEB-to-partner and partner-to-TFEB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TFEB versus RASAL3 in HNSC, with a Pearson correlation of 0.47.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TFEB→partner) and Y-score (partner→TFEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RASAL3 →	+0.497	+0.459	<.001	<.001	3	8
BRCA	RCSD1 →	+0.712	+0.469	<.001	<.001	3	8
GBM	TFEB_S423 →	+1.015	+0.620	<.001	<.001	3	7
GBM	BIN2 →	+0.554	+0.312	<.001	<.001	3	7
LSCC	ARHGAP15_S64 →	+0.924	+0.285	<.001	<.001	3	7
HNSC	SASH3 →	+0.507	+0.412	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 28,013 associations by consensus.

TFEB vs RASAL3 — HNSC

Explore this scatter interactively →