TFEB

Across TCGA patient cohorts, TFEB mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFEB-associated genes across cancer lineages are eIF4E, FASN, and MSH2. Each is linked with TFEB in more than 1 cancer types. Because this analysis shows association rather than direction, both TFEB-to-partner and partner-to-TFEB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TFEB-low versus TFEB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFEB→partner) and Y-score (partner→TFEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.161	+1.847	.038	.008	3	2
UCEC	FASN →	+0.331	+2.999	.022	.035	3	2
UCEC	MSH2 →	-0.185	-2.433	.028	.018	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.404	-2.000	.014	.030	3	2
UCEC	STAT3_pY705 →	-0.463	-3.392	<.001	<.001	3	2
UCEC	ASNS →	+0.423	+2.115	.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

eIF4E by TFEB expression — UCEC

Explore this box plot interactively →