TFEB

Across TCGA cell cohorts, TFEB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,680 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TFEB-associated GO terms across cancer lineages are Regulation of fat cell differentiation, Response to steroid hormone, and Positive regulation of cellular respiration. Each is linked with TFEB in more than 9 cancer types. Because this analysis shows association rather than direction, both TFEB-to-partner and partner-to-TFEB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of fat cell differentiation grouped by TFEB-low versus TFEB-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFEB→partner) and Y-score (partner→TFEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of fat cell differentiation →	+0.051	+1.060	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Response to steroid hormone →	+0.074	+0.870	.001	.004	3	10
URINARY_TRACT	Positive regulation of cellular respiration →	+0.179	+1.117	<.001	<.001	3	9
BONE	Negative regulation of protein-containing complex assembly →	+0.087	+1.090	.002	.001	3	9
BLOOD_Lymphoma	Negative regulation of respiratory burst involved in inflammatory response →	+0.122	+1.519	<.001	<.001	3	9
BLOOD_Lymphoma	Negative regulation of respiratory burst →	+0.122	+1.519	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,680 associations by consensus.

Regulation of fat cell differentiation by TFEB expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →