TFEB

Across TCGA cell cohorts, TFEB mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TFEB-associated genes across cancer lineages are LYZL1, OR1L6, and TXNDC8. Each is linked with TFEB in more than 1 cancer types. Because this analysis shows association rather than direction, both TFEB-to-partner and partner-to-TFEB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL1 grouped by TFEB-low versus TFEB-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFEB→partner) and Y-score (partner→TFEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LYZL1 →	+0.045	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.019	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	TXNDC8 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	SCYGR1 →	+0.144	+5.228	.002	.005	3	1
BLOOD_Leukemia	GSC →	+0.693	+2.948	.009	.008	3	1
BLOOD_Leukemia	KAAG1 →	+0.069	+3.177	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

LYZL1 by TFEB expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →