TFE3

Across TCGA pan-cancer cohorts, TFE3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TFE3 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TFE3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TFE3 expression acts as an unfavorable survival marker.

HNSC, CCRCC, and LUAD are the cancer types where TFE3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.316	0.886	.012	20	view →
CCRCC	OS	Median	III,IV	0.584	0.837	.006	7	view →
LUAD	DFS	Median	All	0.492	0.704	.043	2	view →
PDAC	OS	Median	III,IV	0.396	0.769	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TFE3–HNSC (DFS)

Open the HNSC breakdown →