TFCP2L1

Across TCGA patient cohorts, TFCP2L1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TFCP2L1-associated genes across cancer lineages are Caspase-8, Acetyl-a-Tubulin-Lys40, and INPP4B. Each is linked with TFCP2L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFCP2L1-to-partner and partner-to-TFCP2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by TFCP2L1-low versus TFCP2L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TFCP2L1→partner) and Y-score (partner→TFCP2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.244	-3.558	.015	.002	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.746	+2.321	.006	.035	3	1
UCEC	INPP4B →	-0.318	-2.459	.014	.018	3	1
UCEC	Ku80 →	+0.198	+1.498	.037	.036	3	1
UCEC	MEK1 →	+0.568	+3.087	<.001	<.001	3	1
UCEC	mTOR_pS2448 →	-0.152	-2.446	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Caspase-8 by TFCP2L1 expression — UCEC

Explore this box plot interactively →