TFCP2L1

Across TCGA cell cohorts, TFCP2L1 protein abundance is significantly associated with the go_rna of many other GO terms, with 114 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible TFCP2L1-associated GO terms across cancer lineages are Regulation of Rho protein signal transduction, Regulation of mitochondrion organization, and Myotube differentiation involved in skeletal muscle regeneration. Each is linked with TFCP2L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TFCP2L1-to-partner and partner-to-TFCP2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of Rho protein signal transduction grouped by TFCP2L1-low versus TFCP2L1-high in KIDNEY.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TFCP2L1→partner) and Y-score (partner→TFCP2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of Rho protein signal transduction →	+0.159	+0.955	.002	.003	3	2
KIDNEY	Regulation of mitochondrion organization →	+0.134	+0.933	.002	.008	3	1
KIDNEY	Myotube differentiation involved in skeletal muscle regeneration →	+0.273	+0.933	<.001	.008	3	1
KIDNEY	L-glutamate transmembrane transport →	-0.132	-0.933	<.001	.008	3	1
KIDNEY	Cellular response to forskolin →	+0.229	+0.933	<.001	.008	3	1
KIDNEY	Negative regulation of ubiquitin protein ligase activity →	-0.263	-0.933	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

Regulation of Rho protein signal transduction by TFCP2L1 expression — KIDNEY

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